Kolgen Kowa Ibtx Alpha 45 Tablets Kowa [Designated Class 2 Drug]

Relief of cold symptoms (sore throat, fever, runny nose, stuffy nose, sneezing, cough, phlegm, chills, headache, joint pain, muscle pain)

[Main component]
(out of 9 tablets)
ibuprofen 600mg
Tranexamic acid 750mg
Ambroxol hydrochloride 45mg
d-chlorpheniramine maleate 3.5mg
Dihydrocodeine phosphate 24mg
dl-methylephedrine hydrochloride 60mg
Anhydrous caffeine 75mg

[Additives]
Silicic anhydride, hypromellose, citric acid, lactose, Ca silicate, hydroxypropyl cellulose, carmellose Ca, Mg stearate, triacetin, talc, titanium oxide, Yellow No. 5, carnauba wax

Please take the following amount with water or warm water preferably within 30 minutes after meals.

[Age: Dose: Number of doses per day]
Adults (15 years and older): 3 tablets: 3 times
Children under 15 years of age: Do not take

1. Do not use the following people
(1) Persons who have had allergic symptoms due to this drug or its ingredients.
(2) People who have had asthma while taking this drug or other cold medicines or antipyretic analgesics.
(3) Children under the age of 15.
(4) Persons receiving treatment or medication for the following illnesses at a medical institution.
Stomach/duodenal ulcer, blood disease, liver disease, kidney disease, heart disease, high blood pressure, people taking zidovudine (Retrovir)
(5) Pregnant women within 12 weeks of due date.
2. Do not use any of the following medicines while taking this drug:
Other cold medicines, antipyretic analgesics, sedatives, antitussive expectorants, oral medicines containing antihistamines (oral medicines for rhinitis, motion sickness medicine, allergy medicines, etc.), oral medicines containing tranexamic acid.
3. Do not drive a vehicle or operate machinery after taking this medicine.
(Drowsiness, etc. may occur.)
4. Do not take this drug if you are breastfeeding, or avoid breastfeeding if you are taking this drug.
5. Do not drink alcohol before or after taking the drug
Do not take for more than 6.5 days

1. The following people should consult a doctor, pharmacist, or registered salesperson before taking the drug.
(1) Persons receiving treatment from a doctor or dentist.
(2) Pregnant women or people who appear to be pregnant.
(3) Elderly people.
(4) People who have had allergic symptoms due to medicines, etc.
(5) People who have the following symptoms. High fever, difficulty urinating
(6) Persons who have received the following diagnosis.
Thyroid dysfunction, diabetes, glaucoma, systemic lupus erythematosus, mixed connective tissue disease, people with blood clots (cerebral thrombosis, myocardial infarction, thrombophlebitis), people at risk of thrombosis, bronchial asthma, respiratory dysfunction, obstructive sleep apnea syndrome, obesity.
(7) Persons who have had the following diseases.
Stomach/duodenal ulcer, ulcerative colitis, Crohn’s disease, blood disease, liver disease, kidney disease
2. If the following symptoms appear after taking this medicine, it may be a side effect, so please stop taking it immediately and consult your doctor, pharmacist, or registered salesperson with this package insert.
[Related area: Symptoms]
Skin: Rash/redness, itching
Gastrointestinal: Nausea/vomiting, loss of appetite, stomach discomfort, stomach pain, stomatitis, heartburn, heaviness in the stomach, gastrointestinal bleeding, abdominal pain, diarrhea, stomach/abdominal bloating.
Neuropsychiatric system: dizziness, insomnia, depressed mood
Cardiovascular: palpitations
Respiratory: shortness of breath
Urinary system: difficulty urinating
Other: Blurred vision, ringing in the ears, swelling, back pain, numbness
●In rare cases, the following serious symptoms may occur. In that case, please see a doctor immediately.
[Symptom name: Symptom]
Shock (anaphylaxis): Immediately after taking the drug, symptoms such as itchy skin, hives, hoarseness, sneezing, itchy throat, difficulty breathing, palpitations, and clouded consciousness may occur.
Oculomucocutaneous syndrome (Stevens-Johnson syndrome): High fever, bloodshot eyes, mucus, sore lips, sore throat, and widespread skin rash/redness that persist or worsen rapidly.
Toxic epidermal necrolysis: High fever, bloodshot eyes, mucus, sore lips, sore throat, and widespread rash/redness on the skin persist or worsen rapidly.
Liver dysfunction: Fever, itching, rash, jaundice (yellowing of the skin and whites of the eyes), brown urine, general malaise, loss of appetite, etc. may appear.
Kidney disorder: Fever, rash, decreased urine output, general swelling, general malaise, joint pain (pain in the joints), diarrhea, etc. may appear.
Aseptic meningitis: Severe headache accompanied by stiffness in the neck, fever, nausea, and vomiting appear. (Such symptoms are especially common in people receiving treatment for systemic lupus erythematosus or mixed connective tissue disease.

(1) Avoid high temperatures and store in a cool, dry place out of direct sunlight.
(2) Please keep out of reach of children.
(3) Do not transfer to another container. (It may cause misuse or change in quality.)
(4) Please be careful when storing and carrying the PTP to avoid tearing the aluminum foil or deforming the capsule inside.
(5) Do not take the product after the expiration date (written on the outer box).

Kowa Co., Ltd. Pharmaceutical Division Customer Consultation Center
3-4-14 Nihonbashi Honmachi, Chuo-ku, Tokyo 103-8433
03-3279-7755