Matsukiyo Zero Shut Antidiarrheal 12 Tablets [Designated Class 2 Pharmaceuticals]

Diarrhea, diarrhea due to overeating/drinking, diarrhea due to cold sleep, diarrhea with abdominal pain, perishable food, perishable water, loose stools

4 tablets in total
Loperamide hydrochloride…1mg
(Acts directly on the intestines to improve excessive intestinal motility and water absorption and abnormal secretion in the intestinal mucosa, thereby suppressing diarrhea.)
Berberine chloride hydrate…80mg
(Exhibits excellent bactericidal action against harmful bacteria in the intestines and prevents abnormal fermentation and putrefaction in the intestines.)
Acrinol hydrate…80mg
(Exhibits excellent bactericidal action against harmful bacteria in the intestines and prevents abnormal fermentation and putrefaction in the intestines.)
[Additives]
Lactose hydrate, crystalline cellulose, crospovidone, corn starch, hypromellose, hydroxypropylcellulose, light silicic anhydride, titanium oxide, magnesium stearate, macrogol 6000, carnauba wax

Please take the following amount. However, do not take this medicine if the diarrhea stops.
Also, please wait at least 4 hours between doses.
Adults (15 years and older): 2 tablets per dose, 2 times per day
Under 15 years of age: Do not take
[Precautions related to usage and administration]
(1) Please strictly follow the prescribed usage and dosage.
(2) How to take out the tablet
Press the convex part of the PTP sheet containing the tablet firmly with your fingertips to break the aluminum foil on the back, take it out, and take it.
(If you accidentally swallow it whole, it may pierce the esophageal mucosa or cause an unexpected accident.)

1. Do not take this medicine for the following people:
・Persons who have had allergic symptoms due to this drug or its ingredients
2. Do not take the following medicines while taking this drug.
・Gastrointestinal analgesic and antispasmodic drug
3. Do not drive a vehicle or operate machinery after taking this medicine. (Drowsiness, etc. may occur.)
4. Do not drink alcohol before or after taking this medicine.

1. The following people should consult a doctor, pharmacist, or registered salesperson before taking this medicine.
(1) Persons receiving treatment from a doctor
(2) People with diarrhea accompanied by fever, bloody stools, or persistent mucus stools
(3) Persons with acute severe diarrhea or diarrhea accompanied by symptoms such as abdominal pain, abdominal distension, and nausea.
(Forcibly stopping diarrhea with this drug may actually make the disease worse.)
(4) People with anal diseases etc. who must avoid constipation
(Constipation may occur when taking this drug.)
(5) Pregnant women or people who appear to be pregnant.
(6) People who are breastfeeding
(7) Elderly people
(8) People who have had allergic symptoms due to drugs, etc.
2. If the following symptoms appear after taking this medicine, it may be a side effect, so stop taking it immediately and consult your doctor, pharmacist, or registered salesperson with this document.
(1) If the following symptoms appear after taking the drug:
[Related areas: Symptoms]
・Skin: Rash, redness, itching
・Digestive system: Constipation, abdominal bloating, abdominal discomfort, abdominal pain, nausea/vomiting, loss of appetite
・Psychiatric nervous system: dizziness
In rare cases, the following serious symptoms may occur. In that case, please see a doctor immediately.
[Symptom name: Symptom]
・Shock (anaphylaxis): Immediately after taking the drug, symptoms such as itchy skin, hives, hoarseness, sneezing, itchy throat, difficulty breathing, palpitations, and clouded consciousness may occur.
・Ileus-like symptoms (intestinal obstruction-like symptoms): Severe abdominal pain, cessation of gas expulsion (farts), vomiting, and severe constipation accompanied by a feeling of abdominal distention appear.
・Oculomucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome): High fever, bloodshot eyes, mucus, sore lips, sore throat, widespread rash/redness on the skin, etc. persist or worsen rapidly.
3. If your symptoms do not improve after taking this medicine for 2 to 3 days, please stop taking it and consult your doctor, pharmacist, or registered salesperson with this document.

(1) Avoid high temperatures and store in a cool, dry place out of direct sunlight.
(2) Please keep out of reach of children.
(3) Do not transfer to another container. (This may cause misuse or change in quality.)
(4) Be careful when storing and carrying the PTP to avoid tearing the aluminum foil or damaging the tablets inside.
(5) Do not take the product after the expiration date (written on the outer box).

Daisho Pharmaceutical Co., Ltd. Customer Service Office
168 Ohara Market, Koka-cho, Koka-shi, Shiga Prefecture
0748-88-4181
Reception hours 9:00-17:00
(Excluding Saturdays, Sundays, and holidays)